The department is clearly based on the Los Angeles Fire Department. The LSFD shows support for the lost FDLC firefighters with an insignia appearing on the Fire Truck. According to the logo, the LSFD was founded in 1888. The Los Santos Fire Department seal appears on the back of the Lifeguard SUV, as well as on the exterior of the Los Santos International Airport Fire Station, while the Los Santos Fire Rescue appears on both the Fire Truck and on the El Burro Heights Fire Station exterior. The vehicle livery design also bears the Los Santos County seal on the doors. There are various examples of the Los Santos County Fire Department seal within fire stations and on the Fire Truck.

They also have a lifeguard division, the Los Santos Lifeguard that may be found at Vespucci and Del Perro beaches. In addition to providing fire protection, the LSFD also provides a medical service which operate Ambulances.

Furthermore, decals on the Fire Truck, among various seals and logos found on apparatus and within fire stations, name the department 'Los Santos County' and 'Los Santos City', suggesting the department is a amalgamation of the three major jurisdictions of San Andreas. Despite the name localizing the department to 'Los Santos', the service is available and apparent across the entirety of San Andreas, including Blaine County. The LSFD operate Fire Trucks and Ambulances in their service, and have several stations across San Andreas.

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